Although Melchert began his artistic career as a conceptually oriented painter, he is perhaps best known today for a unique process that involving ceramic tiles: he breaks, draws on, reassembles, and paints on them with low-fire glazes. His interest in natural and scientific phenomena is reflected in his process-oriented works, which have an organic and expressive quality. Melcherts aesthetic is based on a belief in the dualities of nature. Oppositions of chance and control, the intuitive versus the intellectual, and the handmade against manufactured all find expression in his organic, process-oriented works. In many of his projects, including the 225-foot-long mural in the lobby of MITs Biology Building, Melchert orients himself within the broader context of the project, integrating his work within the overall design.